We have developed a multiplex approach, based on programmable magnetic nanowires and bits patterned on a platform, to simultaneously apply directed forces on multiple fluid-borne cells or biologically inert magnetic nanoparticles. Underlying the functionalities of this new magnetic tweezers are tunable femto- to pico-Newton range forces that do not produce cell damage. Building upon the early successes of manipulating magnetically labeled and unlabeled cells, our recent efforts have enabled control over competing deterministic (magnetic) and stochastic (Brownian) forces for targeted drug delivery and transport of micelle nano-containers encapsulating separate quantum dots and nanoparticles. The advantages and challenges of these joystick and voice activated approaches will be discussed as we move towards realizing new intra-cellular probes and nano-scale devices.