In vivo and In vitro Imaging of Silicon Nanowires
Friday December 11, 2009
Refreshments will be served at 3:00 PM in Room 298
Chen Yang
Purdue University
http://www.chem.purdue.edu/yang/
Understanding properties in nanostructures have opened up opportunities for technological applications and fundamental studies. An intensive non-linear optical emission has been demonstrated from nanowires as small as 5 nm in diameter. The nonlinear optical signal shows a cos6 dependence on the polarization of excitation with respect to the nanowire axis. The third-harmonic generation signal from the nanowires is found to be highly photostable with an intensity level of 10 times larger than that from silver nanoparticles of similar size. The nonlinear optical signal allows intravital imaging of PEGylated nanowires circulating in the peripheral blood of a mouse and mapping of nanowires accumulated in the liver and spleen. Nonlinear optical imaging of nanowires offers new and exciting opportunities to investigate the behavior of one-dimensional nanomaterials in live cells and in vivo.
