Sources of Bias in Time-of-Flight Measurements - Riei Ishizeki The CDF experiment studies high energy proton anti-proton collisions produced at the Fermilab Tevatron collider, located near Chicago, Illinois. The CDF-II detector uses a Time-of-Flight detector, based on plastic scintillator and photomultiplier tubes, to identify charged kaons, pions and protons produced in proton anti-proton collisions. After applying calibrations to the data recorded with the TOF detector, residual biases were still observed in the measured arrival times of protons and kaons. The studies carried out here indicated that a significant contribution to this bias comes from the detailed way in which light propagates in plastic scintillator and the way the electrical signal produced by the photomultiplier tube interacts with the front-end electronics. Application of this model to the calibration of the TOF detector is expected to improve the timing resolution obtained at CDF, but should also be applicable to a wide range of similar TOF detector systems.