Calcium resorption from bone in a human studied by 41Ca tracing

B.R. Johnson, D. Berkovits, E. Boaretto, Z. Gelbart, S. Ghelberg, M. Paul, V. Sossi, Hebrew University, Israel

O. Meirav, E. Venczel, TRIUMF, Vancouver, Canada

J. Prior, University of British Columbia, Canada

Nuclear Instruments and Methods 92 (1994) 483-488

We are investigating long- and short-term processes that involve the resorption of the bone calcium in the human body, using accelerator mass spectrometry of 41Ca (T1/2 = 104000 years). The evolution of an injected dose of 41Ca has been followed over 900 days by measurements in urine and serum. The 41Ca/Ca isotopic ratio rapidly decreased after injection and after about 100 days, reached a quasi-steady state of 1.5 x 10^-11. Variations in this level would signal a change in rates of calcium resorption from the bone.