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  Ken Ritchie

Associate Professor of Physics

kpritchie@purdue.edu
Office: Physics 58
Telephone: (765) 496-8315
Fax: (765) 494-0706
Laboratory homepage

B.Sc., Physics, University of Waterloo
M.Sc., Physics, University of Waterloo
Ph.D., Physics, University of British Columbia

Research Interests

  • Dynamics of the formation of signaling complexes in the plasma membrane of cells.
  • Diffusion in lipid bilayer membranes with embedded mobile and immobile obstacles.
  • Development of ultra-fast imaging techniques for observing individual molecules in living cells.
  • Single molecule biophysics.

Teaching Interests

  • Spring 2006: PHYS 630 Classical Electrodynamics
  • Fall 2006: PHYS 570X Introduction to Biophysics

Professional Experience

  • 1998-2003 Group leader and researcher, Kusumi Membrane Organizer Project, ERATO, Japan Science and Technology Co., Nagoya, Japan
  • 2000-2005 Assistant professor, Department of Biological Science, Nagoya University, Nagoya, Japan

Selected Publications

  1. Ritchie, K., Shan, X.-Y., Kondo, J., Iwasawa, K., Fujiwara, T. and Kusumi A. (2005) Detection of non-Brownian diffusion in the cell membrane in single molecule tracking. Biophys. J. 88:2266-2277.
  2. Koyama-Honda, I., Ritchie, K., Fujiwara, T., Iino, R., Murakoshi, H., Kasai, R.S. and Kusumi, A. (2005) Fluorescence imaging for monitoring the colocalization of two single molecules in living cells. Biophys. J. 88:2126-2136.
  3. Murase, K., Fujiwara, T., Umemura, Y., Suzuki, K., Iino, R., Yamashita, H., Saito, M., Murakoshi, H., Ritchie, K. and Kusumi A. (2004) Ultrafine membrane compartments for molecular diffusion as revealed by single molecule techniques. Biophys. J. 86:4075-4093.
  4. Ritchie, K. and Kusumi, A. (2003) Single particle tracking image microscopy. Methods In Enzymol, 360 "Biophotonics", G. Marriott and Ian Parker, editors. pp. 618-634.
  5. Nakada, C., Ritchie, K., Oba, Y., Nakamura, M., Hotta, Y., Iino, R., Kasai, R. S., Yamaguchi, K., Fujiwara, T. and Kusumi, A. (2003) Accumulation of anchored proteins forms membrane diffusion barriers as neurons develop polarization. Nat. Cell Biol., 5:626-632.
  6. Fujiwara, T., Ritchie, K., Murakoshi, H., Jacobson, K. and Kusumi, A. (2002) Phospholipids undergo hop diffusion in compartmentalized cell membrane. J. Cell Biol. 157:1071-1081.
  7. Merkel, R., Nassoy, P., Leung, A., Ritchie, K., and Evans, E. (1998) Using Dynamic Force Spectroscopy to Explore Energy Landscapes of Receptor-Ligand Bonds Nature, 397:50-53.
  8. Evans, E. and Ritchie, K. (1997) Dynamic strength of molecular adhesion bonds. Biophys. J., 72:1541-1555.