David D. Nolte
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Professor of Physics contact me Office: Physics 54 Telephone: (765) 494-3013 Fax: (765) 494-0706 Resume |
Ph.D., 1988 Department of Physics, University of California, Berkeley
B.A., 1981 Department of Physics, Cornell University
Research Interests
Current: The adaptive optics and biophotonics group, directed by Professor Nolte, studies a broad spectrum of problems that range from BioCDs (Biological Compact Disks) that rely on diffraction of lasers from spinning discs supporting antibodies, to real-time video flythroughs of rat bone-cancer tumors using holographic imaging, and microfabrication of microfluidic systems using two-photon polymerization. The BioCD uses high-speed spinning-disc interferometry (SDI) to measure average changes in protein heights with sensitivities down to a picometer. These silicon discs are protein microarrays that have the ability to screen for hundreds of types of molecules across hundreds of samples. Holographic optical coherence imaging (HOCI) has high sensitivity to motion inside of tissues and cells. Using digital holography, we are studying the effects of anti-cancer drugs on the cytoskeleton. Laser machining using two-photon polymerization is a direct-write process that fabricates complex microfluidic systems. These projects use laser interferometry, nonlinear optics, coherent optics, and Fourier optics to study aspects of biological systems from the nanoscale molecular level to the macroscale tissue level.
Projects
· The BioCD: Bio-optical Compact Disk
| BioCDSPIE03.pdf
| BioCDOL.pdf
| BioCDBB.pdf | AOBioCDAPL.pdf | ZhaoClinChem06.pdf |
· Optical Coherence Imaging (OCI)
| TumorOCI.APL.pdf
| SpeckleOCI.OL.pdf
| JeongAO04.pdf |
SPIEMagazineDN2.pdf |
· Self-Adaptive Holography
· Photorefractive Quantum Wells
| PIN.pdf
| ASFP.pdf
| Review.pdf |
· Mesoscopic Point-Like Defects in Semiconductors
| Meso.pdf
| Cluster.pdf |
· Fsec Adaptive Holography
| Combine.pdf
| Adaptive.pdf
| Shape.pdf |
· Time-Reversed Light
· Fibonacci Physics
· Super-Diffusion in AlAs/GaAs Quantum Wells
· Shimmering Holograms in Quantum Nanostructures
· Controlling Light with Light
· Quantum Engineering the Holographic Ear
| LBU.pdf
| Oscillate.pdf
| Moving.pdf |
Research Groups
· Adaptive Optics and Biophotonics Group under the direction of Prof. David D. Nolte
· Biophysics
· The BioCD Antibody molecule attached to a BioCD for selective detection of antigen and blood proteins. The BioCD has the potential for high-speed, multi-analyte, high-sensitivity sensing for immunoassays and proteomics.
· Prof. Nolte is a technical founder of Quadraspec, Inc. of West Lafayette, IN, a company of 50 employees that is commercializing the immuno-diagnostic potential of the BioCD (http://www.quadraspec.com/).
Review Article
"Semi-insulating semiconductor heterostructures: Optoelectronic properties and applications", J. Appl. Phys. 85, 6259 (1999)
Book
D. Nolte is the author of the trade Non-fiction book "Mind at Light Speed" on the physics and future of photonic technology (Amazon.com).
In the News
· Lasers light way to 3-D imaging in Purdue lab
· BioCDs could hit No. 1 on doctors' charts
· Holographic images use shimmer to show cellular response to anticancer drug
Awards and Honors
· Indiana MIRA Award for Business Innovation of the Year, 2006
Presented to QuadraSpec, Inc., West Lafayette, IN.
· Herbert Newby McCoy Award, Purdue University, 2005
The top award of Purdue University for Discovery in Science.
· PRC National Invited Lecturer, Nankai University, 2004
· Purdue University Faculty Scholar, 2003-2008
· Fellow, American Physical Society, 2003
· Fellow, Optical Society of America, 1997
· Joel and Ruth Spira Award for Undergraduate Teaching, 1997
· Presidential Young Investigator, NSF 1991-1996
· Research Initiation Award, NSF 1990-1993
· Alfred P. Sloan Research Fellowship, 1990-1994
· Young Author Best Paper Award, International Conference on the Physics of Semisconductors, 1990
· Phi Beta Kappa, 1981
· National Merit Schoarship, 1977
Professional Experience
· Technical Founder and Consultant, QuadraSpec, Inc., W. Lafayette, IN, 2004-
· Member, Board of Directors of Holoscan, Ltd. UK, 2000-2004
· NATO Consultant for Science for Peace Program, 2000-2002
· Full Professor, Dept. of Physics, Purdue University, 1999-
· Associate Professor, Dept. of Physics, Purdue University, 1994-1999
· Assistant Professor, Dept. of Physics, Purdue University, 1989-1994
· Postdoctoral Member of Technical Staff, AT&T Bell Labs (advisor A. M. Glass), 1988-1989
· Research Assistant, Center for Advanced Materials, Lawrence Berkeley Laboratory (advisor E. Haller & L.M. Falicov), 1984-1988
