High-energy galactic cosmic rays permeate the entire solar system, producing a variety of nuclides in materials exposed to these energetic particles. In meteorites, cosmogenic nuclides can be used to delineate the duration of their transport from parent bodies to collision with Earth. In terrestrial materials, their concentrations provide critical information about processes influencing the shaping of Earth’s landscape. For both terrestrial and extra-terrestrial applications, the combination of cosmogenic radio- and stable nuclides provides information over a wide range of time-scales, from millions, to tens of millions of years.