Contact Information
Department of Physics525 Northwestern Avenue
West Lafayette, IN
47907-2036
Map and Directions
Telephone:
(765) 494-2970
Fax:
(765) 494-0706
Jeremy Rogers
Northwestern University
Cell and tissue metrology via Enhanced Backscattering Spectroscopy: quantification of nano-scale mass density distributions and fractal dimension.
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Tuesday October 18, 2011
3:30pm PHYS 242
Coffee and doughnuts served at 3:15pm.
http://ultraviolet.bme.northwestern.edu/~jdrogers/Cellular life is fundamentally governed by physical processes at a macro-molecular scale (i.e. tens to hundreds of nanometers), but observation of these scales is challenging. This is especially true for living cells and tissue since most high resolution imaging methods require fixation, staining, sectioning, and other processing that can easily alter the fragile nano-architecture. Yet changes in this nano-architecture have been linked to early stages of carcinogenesis, and understanding these changes will provide insight into the basic language of cells, namely protein expression, as well as other fundamental cell processes. Fortunately, noninvasive quantification of nano-architecture, including mass-fractal dimension, is possible using light scattering methods such as enhanced backscattering spectroscopy, polarization gating, as well as spectral OCT and spectral microscopy.